The Social Innovation Lab emphasizes not only imagining high potential interventions but also gaining system sight, redefining problems, and identifying opportunities in the broader context with the potential to tip systems in positive directions. It is a three-step process of developing, testing and instigating innovation strategies. It requires the right starting conditions, an investment in research and skilled facilitators. It also makes use of computer modeling to proto-typing interventions in complex systems. Like other processes for convening multi-stakeholder groups working on complex challenges, it is best suited to the early stages of making change. This guide is offered as a resource to peers, colleagues, practitioners, leaders from all sectors, and concerned citizens - all who have and/or will participate in change-making processes. One hope for this work is that these ideas on Social Innovation and these recommendations for new practice will result in greater sense of agency for those who work on what often seems like impossible aspirations for a different, better world. Probably our greatest hope is that these ideas help to transform the impossible into the possible.